Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0456069
PubChem CID
Molecular Formula
C53H84N22O16S4
Molecular Weight
1413.661 g/mol
Synonyms/Alias
N/A (Not available)
InChI Key
SKECDWJKUTVEDU-ICYBEGSVSA-N
InChI
InChI=1S/C53H84N22O16S4/c54-19-38(78)65-34-22-93-95-23-35-47(88)67-27(5-1-13-62-51(56)57)41(82)69-30...
IUPAC Name
2-[(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-40-[(2-aminoacetyl)amino]-24-carbamoyl-4,27,33-tris[3-(diaminomethylideneamino)propyl]-16-(hydroxymethyl)-30-[(4-hydroxyphenyl)methyl]-3,6,12,15,18,26,29,32,35,41-decaoxo-21,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decazatricyclo[17.16.7.07,11]dotetracontan-13-yl]acetic acid
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

179182 0 0 0 0 0 0 0 0999 V2000
-5.6934 -6.3094 -1.5040 N 0 0 0 0 0 0 0 0 0 0 0 0
-6.0038 -5.9196 -2.8800 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.8622 -5.185...

Experimental Data

Activity Data

Target Ion Channel
Neuronal acetylcholine receptor; alpha9/alpha10
Uniprot Accession Number
Function
Antagonist
Species
Homo sapiens (Human)
IC50
IC50: 249 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.4
Holding Potential
−70 mV mV
Temperature
21−24 °C
Test Method
Patch-clamping
Test Species
Xenopus laevis oocyte

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
95
Rotatable Bonds
20
logP
-8.7355
Complexity
350.7246
TPSA (Ų)
643.88
H-Bond Donors
24
H-Bond Acceptors
23
Ring Count
4
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